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Marijuana
Marijuana is a very complex plant: many different strains with differing profiles of psychoactive, non-psychoactive, and peripherally-active compounds that impact metabolism. Most have THC, which...
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Some nuances of Intermittent Fasting
Intermittent fasting (IF) is not a universal panacea, regardless of whether you’re not eating anything at all for a few days each week/month or just restricting your feeding window to a few hours per...
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“Insulin Dynamics”
This one has a bit for everyone. Relationship of Insulin Dynamics to Body Composition and Resting Energy Expenditure Following Weight Loss (Hron et al., 2015) I think study was actually done a few...
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The “Insulin Index”
Similar to the glycemic index, which is an estimate of the rise in blood glucose after eating a particular food, the insulin index is an estimate of the rise in insulin after eating a particular food....
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Personalized Nutrition by Prediction of Glycemic Responses
“please stop asking gurus how many carbs you need to optimize health” An interesting paper came out recently by Zeevi et al. (2015), showing, in part, that we’re all unique snowflakes (in some...
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Insulin resistance is a spectrum
The history of low fat diets is riddled with crappy low fat food-like products. Food quality matters. Insulin resistance is a spectrum Take a group of obese people and assess insulin sensitivity...
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Social jet lag
Social jet lag is basically a general term that refers to circadian arrhythmia. Sort of like insulin resistance, it’s rampantly abundant — some have estimated a prevalence of up to 75%! Social jet...
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the insulin-obesity hypothesis is under attack
…but it isn’t dead, imo, because that would be really hard to do. Like, seriously. Wait, which “insulin hypothesis” was falsified? pic.twitter.com/31pOP9B6Ff — Bill Lagakos (@CaloriesProper) May 11,...
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Insulin resistance and obesity
Some people believe insulin resistance (IR) causes obesity, and they are not pleased when I say this is actually a controversial topic in the field… “Bill isn’t toeing the company line. Again.” So I...
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Circadian timing with REV-ERB and PERIOD
The circadian proteins Bmal and casein kinase (CK) enhance and degrade Period (PER), respectively, by completely different mechanisms. Both are necessary, but at different times of day… #context Gross...
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Circadian arrhythmia in different types of obesity
This study was pretty interesting. Three groups of women: 1) normal weight 2) gynoid obesity (stores more fat in hips & butt), defined by WC/HC < 0.85 3) android obesity (stores more fat in...
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Keto myths & facts
:::begin rant::: Trigger warning? Maybe. Disclaimer: I’m pro-LC (P<0.05), but not anti-LF because LF works better than LC for some people. And with the exception of things like keto for...
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The Hunger-Free Diet(s)
It started out as “lose weight without hunger on LCHF” and went all the way to “effortless fasting on keto.” Works for some and it might be true, but the same can be said for low fat diets! The key,...
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GLP-101
Insulin secretion happens pretty quickly after a meal, in part, due to nutrients and gut-derived incretins like GLP-1. GLP-1 secretion only happens with a meal, so the insulinemic response to oral...
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The BROAD Study or Meat
Is eating meat necessary? Optimal? THE ANSWER MAY SURPRISE YOU Hint: it’s more important to not eat processed refined junk foods. Exhibit A. The BROAD study: a randomized controlled trial using a...
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High protein magic
Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet: randomized control trial (Stentz et al., 2016) n=12/group Duration = 6 months...
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The alkaline diet is bullshit. Proof: vinegar is the bomb
1. Whether it’s Balsamic, sherry, red wine, apple cider, or even plain distilled white, vinegar is a great condiment (P<0.05). Try cutting your favorite with a more concentrated one for more fun (be...
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Allu-lujah: the new Quest Hero bars
Hey fam, I’m moving over to Patreon soon — will still be posting about 4-5 articles per month with at least 1 open to the public. The rest will be for Patrons at $3/month or more. I’m still trying to...
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The importance of entraining skeletal muscle’s circadian clock (and how)
“Literally, every single model of skeletal muscle circadian arrhythmia mimics aging sedentary people who skip breakfast, stay up late, and get sick.” But first, the human studies that confirm these...
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Funded by Big ‘Shrooma
Reishi, the mushroom of longevity. “The goal is to maintain or improve brain function and physical performance. And not get cancer.” [Patron link] ‘Shrooms-every-day is part of my long-term...
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