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Circadian rhythms, sleep deprivation, and human performance

“Much of the current science on, and mathematical modeling of, dynamic changes in human performance within and between days is dominated by the two-process model of sleep-wake regulation, which posits...

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The influence of ketones on intermediary metabolism

Two studies: one on infusion of D-b-hydroxybutyrate at three different level producing up to 2 mM at the highest level (Mikkelsen et al., 2014); and one on ingestion of a ketone monoester...

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Mutual influence of sleep and circadian clocks on physiology and cognition

“The 24-hour sleep-wake cycle is one of the most prominent outputs of the circadian clock systems (Heyde et al., 2018)” [Patron link] Sleep disruption and circadian arrhythmia induce metabolic,...

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Dopamine regulates systemic glucose metabolism in humans

In Four. EPIC. Experiments (ter Horst et al., 2018) Tl;dr: sunlight & breakfast in the morning. [FULL ARTICLE ON PATREON] Dopamine receptors are downregulated in obese patients and are restored in...

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Global rise of potential health hazards caused by blue light

-induced circadian disruptions in modern aging societies (Hatori et al., 2017) [Patron link] While this article could’ve easily addressed the havoc wreaked on most animals (hibernating, migrating,...

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Intermittent Fasting and Goalposts

I may come across as harsh on Intermittent Fasting (IF) and I’d like to be clear about something. I’m not saying IF will make you gain body fat or die a slow and painful death. I am saying the quality...

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Ketogenic diet as a metabolic therapy for mood disorders

Recent findings and current developments: where do we stand today? [Patron link] Great “Tl;dr:” figure ->       There is most definitely a multi-level bidirectional relationship between mood...

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Entrain all of your circadian clocks. Full stop.

Skipping breakfast shifts skin circadian clock and enhances UVB-induced skin aging and cancer (Wang et al., 2017)… ok, that’s not the real title of the paper, but it’s what the research showed. And...

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CARBOTOXICITY [screaming face emoji]

Noxious Effects of Exaggerated Carbohydrate Intake (Kroemer et al., 2018) [Patron link] This blog post is about the above mentioned article. Disclaimer (qualm #1): it is very pro-low carb and refused...

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Deleterious effects of artificial light at night on health and the environment

Evidence summary on how our increasing exposure to artificial blue light is putting us at risk. And actionable steps on what you can do about it. [Patron link] It’s not blue light per se, but rather...

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